Association between different dementia diagnosis and kidney function decline: A Swedish registry study

Background Population studies have shown that chronic kidney disease(CKD) and CKD progression are associated with dementia, particularly Alzheimer’s dementia(AD) vascular dementia(VD). However, the impact of different brain pathogenesis on these associations is not known. Method Observational study patients recently diagnosed dementia disorders from Swedish Dementia Registry(SveDem) 2007-2018 linked complete information function tests [estimated glomerular filtration rate(eGFR)] over time Stockholm CREAtinine Measurements(SCREAM) registry. The exposure were diagnosis [AD, VD, mixed Lewy Bodies(DLB) Parkinson’s disease dementia(PDD), frontotemporal dementia(FTD), unspecified dementia(UNS) other types]. outcome was progression, defined as composite a sustained eGFR decline of>30% baseline, initiation replacement therapy or death attributed to disease. We performed competing risk analyses where non-renal causes considered events for progression. Confounders included demographics, comorbidities, baseline function. Result 20,618 patients, whom, 6,452(31%) had AD, 7,012(34%) 3,987(19%) 764(4%) DLB PDD, 312(2%) FTD, 2,091(10%) diagnoses. mean age 80 years (60%female). During median follow-up 2.5 (IQR1.0-4.5) years, 2,225(11%) occurred, along 8,684(42%) deaths. After adjusting confounders accounting risks, higher compared AD observed VD [sub-HR, 95%CI 1.19;1.05-1.34], (1.13;1.02-1.26), UNS types (1.13;0.96-1.32), while PDD 46% lower (0.54;0.39-0.76), those FTD showed no difference (0.99;0.64-1.51). Conclusion (vs diagnosis) whereas Since involve less more pathology, this suggests mechanisms may play an important role in brain-kidney axis. Future needed explore hypothesis.